METHOD FOR CONTROLLING EXTRAVASATION OF LEUKOCYTE,申请号JP19880201022-传众专利搜索

METHOD FOR CONTROLLING EXTRAVASATION OF LEUKOCYTE

申请公布号：JPH02196(A)

申请号：JP19880201022

申请日期：1988.08.11

申请公布日期：1990.01.05

申请人：

UNIV LELAND STANFORD JR

发明人：YUUJIN SHII BUTSUCHIYAA;SAAPA TEII JIYARUKANEN

分类号：C12P21/08;A61K38/00;A61K39/395;C07K14/00;C07K14/435;C07K14/705;C07K16/00;C07K16/28;C12R1/91

主分类号：C12P21/08

摘要：Novel antibodies that recognize endothelial cell surface molecules or synovial-specific leukocyte homing receptors and block leukocyte extravasation are provided. These antibodies recognize either tissue-specific endothelial cell surface molecules or a synovial-specific leukocyte cell surface glycoprotein and block lymphocyte migration from the blood into tissues such as mucosal lymphoid organs, peripheral lymph nodes, and synovium. Also described are novel endothelial cell surface proteins involved in leukocyte extravasation, having a molecular weight of approximately 58,000 to 69,000 daltons, which express a tissue-specific determinant, as well as a synovial-specific leukocyte glycoprotein of approximately 90,000 daltons. The antibodies are used in compositions to treat individuals having a disease or inflammation-associated pathology in which leukocyte extravasation plays a role.