DERIVATIVES OF 4-(3-ALKYNYLOXY-2-HYDROXY-PROPYL)-PIPERAZIN-1-YL-N-PHENYL ACETAMIDE, THEIR PREPARATION AND THEIR THERAPEUTICAL USE,申请号EP19840401824-传众专利搜索

DERIVATIVES OF 4-(3-ALKYNYLOXY-2-HYDROXY-PROPYL)-PIPERAZIN-1-YL-N-PHENYL ACETAMIDE, THEIR PREPARATION AND THEIR THERAPEUTICAL USE

申请公布号：EP0143016(B1)

申请号：EP19840401824

申请日期：1984.09.14

申请公布日期：1987.07.29

申请人：

RIOM LABORATOIRES- C.E.R.M. "R.L.-CERM" - (S.A.)

发明人：COMBOURIEU, MICHEL;LAIGLE, JEAN-CLAUDE;REYJAL, JEAN-FRANCOIS;LANDES, MARIE-PAULE

分类号：C07D295/14;A61K31/495;A61P9/08;A61P9/10;C07D295/15

主分类号：C07D295/14

摘要：1. Compounds of the formula : see diagramm : EP0143016,P9,F1 wherein R1 represents hydrogen or an alkyl radical linear or branched having 1-6 C atoms ; R2 and R3 represent separately a phenyl radical, an alkyl radical linear or branched having 1-6 C atoms, or together with the carbon atom to which they are bounded a cycloalkyl radical of 5 to 7 C atoms ; R4 represents hydrogen or an alkyl radical linear or branched having 1-6 C atoms ; R5 represents an alkyl radical linear or branched having 1-6 C atoms or phenyl radical optionally substituted by a halogen atom ; X represents hydrogen or halogen atom, and pharmaceutically acceptable addition salts thereof.