YEAST PRODUCTION OF HEPATITIS B SURFACE ANTIGEN,申请号ZA19860008601-传众专利搜索

YEAST PRODUCTION OF HEPATITIS B SURFACE ANTIGEN

申请公布号：ZA8608601(B)

申请号：ZA19860008601

申请日期：1986.11.12

申请公布日期：1987.06.24

申请人：

PHILLIPS PETROLEUM COMPANY

发明人：JUERG FRIEDRICH TSCHOPP;MICHAEL MILLER HARPOLD;JAMES MICHAEL CREGG;RICHARD GORDON BUCKHOLZ

分类号：C12N15/09;A61K39/29;C07H21/04;C07K14/02;C12N1/16;C12N1/19;C12N15/00;C12N15/51;C12N15/81;C12P21/00;C12R1/84

主分类号：C12N15/09

摘要：Novel DNA constructs comprising regulatory regions plus the structural coding region for hepatitis B surface antigen (HBsAg) are disclosed. The regulatory regions employed are responsive to methanol, non-catabolite repressing carbon sources and catabolite repressing carbon sources followed by carbon source starvation. The novel constructs are incorporated into a variety of linear and circular plasmids. Such plasmids are used to transform suitable hosts and ultimately used for the production and isolation of hepatitis B surface antigen in high yields.