Substituted pyrroles with opioid receptor activity

申请公布号：US4649200(A)

申请号：US19860861051

申请日期：1986.05.08

申请公布日期：1987.03.10

申请人：

REGENTS OF THE UNIVERSITY OF MINNESOTA

发明人：PORTOGHESE, PHILIP S.;LIPKOWSKI, ANDRZEJ W.

分类号：C07D491/22;(IPC1-7):C07D491/22

主分类号：C07D491/22

摘要：Substituted pyrroles of the formula: <IMAGE> are disclosed wherein R1 is (C1-C5)alkyl, C3-C6(cycloalkyl) alkyl, C5-C7(cycloalkenyl)alkyl, aryl, aralkyl, trans-(C4-C5) alkenyl, allyl or furan-2-ylalkyl; R2 is H or OH, R3 is H, (C1-C5)alkyl or (C1-C5)alkanoyl and R4 is H or (C1-C5) alkyl; as well as the pharmaceutically-acceptable salts thereof. These compounds are useful as analgesics and/or as selective kappa-opioid antagonists.

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