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Phosphoric acid esters, their preparation and their use for the preparation of biocompatible surfaces.

申请公布号:EP0157469(A1)

申请号:EP19850300356

申请日期:1985.01.18

申请公布日期:1985.10.09

申请人:
BIOCOMPATIBLES LTD.

发明人:CHAPMAN, DENNIS;DURRANI, AZIZ AHMED

分类号:C07F9/09;A61L26/00;A61L33/00;C07C43/315;C07F5/00;C07F9/14;C07F9/6584;(IPC1-7):C07F9/10;C07F9/15;C08J7/12;A61L27/00;C07F9/02;C07F9/65

主分类号:C07F9/09

摘要:<p>A compound of formula &lt;Chemistry id="chema01" num="0001"&gt;&lt;Image id="ia01" he="20" wi="50" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /&gt;&lt;/Chemistry&gt;in which X&lt;Sup&gt;1&lt;/Sup&gt; is a reactive group that can react to form a covalent bond with a reactive group on the surface of a material to be rendered biocompatible, X&lt;Sup&gt;2&lt;/Sup&gt; is a group -O&lt;Sup&gt;e&lt;/Sup&gt; or a precursor of such a group, n is 2, 3 or 4, Y is a group -*NR&lt;Sub&gt;3&lt;/Sub&gt;A&lt;Sup&gt;e&lt;/Sup&gt; wherein each R, which may be the same or different, is a C&lt;Sub&gt;1&lt;/Sub&gt;-C&lt;Sub&gt;4&lt;/Sub&gt; alkyl group and A&lt;Sup&gt;e&lt;/Sup&gt; is an anion present when X&lt;Sup&gt;2&lt;/Sup&gt; is an electrically neutral group or Y is &lt;Chemistry id="chema02" num="0002"&gt;&lt;Image id="ia02" he="10" wi="7" file="IMGA0002.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /&gt;&lt;/Chemistry&gt;wherein R&lt;Sup&gt;1&lt;/Sup&gt; together with X&lt;Sup&gt;2&lt;/Sup&gt; forms a direct bond between the nitrogen and the phosphorus atoms.</p>

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