PREPARATION OF ACYL CYANIDE,申请号JP19840040184-传众专利搜索

PREPARATION OF ACYL CYANIDE

申请公布号：JPS60184056(A)

申请号：JP19840040184

申请日期：1984.03.01

申请公布日期：1985.09.19

申请人：

KOGYO GIJUTSUIN (JAPAN)

发明人：TANAKA MASATO;SAKAKURA TOSHIYASU

分类号：C07D333/24;B01J23/00;B01J23/46;B01J27/00;B01J27/13;B01J31/00;B01J31/20;B01J31/22;B01J31/24;C07B61/00;C07C67/00;C07C253/00;C07C253/30;C07C255/17;C07C255/40;C07C255/56;C07D307/54

主分类号：C07D333/24

摘要：PURPOSE:To obtain the titled compound useful as a synthetic intermediate for heterocyclic compounds in high yield under mild conditions, by reacting a specific cyanohydrin with a hydroperoxide in the presence of a ruthenium catalyst. CONSTITUTION:A cyanohydrin expressed by the formula (R<1> is aryl, alkenyl or heterocyclic ring) is reacted with a hydroperoxide expressed by the formula R<2>COOH (R<2> is alkyl, cycloalkyl or aralkyl) in the presence of a ruthenium catalyst, e.g. metallic ruthenium powder, to give the aimed compound expressed by the formula R<1>COCN. The reaction proceeds rapidly even at room temperature in many cases, and is carried at usually -20-+100 deg.C, preferably 0-80 deg.C. If the relation of the amount between the cyanohydrin and the hydroperoxide is excess in either one thereof, the reaction proceeds. However, the molar ratio between the cyanohydrin and the hydroperoxide is within 0.1-2 preferably 0.2-1 range.