CYCLOPEPTIDES AND PHARMACEUTICAL PREPARATIONS THEREOF AND ALSO PROCESSES FOR THEIR MANUFACTURE,申请号CA19800355189-传众专利搜索

CYCLOPEPTIDES AND PHARMACEUTICAL PREPARATIONS THEREOF AND ALSO PROCESSES FOR THEIR MANUFACTURE

申请公布号：CA1148146(A)

申请号：CA19800355189

申请日期：1980.07.02

申请公布日期：1983.06.14

申请人：

CIBA-GEIGY AG

发明人：RINK, HANS;SIEBER, PETER;KAMBER, BRUNO

分类号：A61K38/00;C07K14/655;(IPC1-7):C07C103/52

主分类号：A61K38/00

摘要：<p>Case 4-12421/1+2/= New cyclopeptides and pharmaceutical preparations thereof and also processes for their manufacture The somatostatin-analogous cyclic octapeptides according to the invention of the general formula (I) in which trp represents L-Trp or D-Trp, in which the benzene ring may be substituted by a halogen atom, and Gaba(Ar) represents the residue of a .gamma.-amino- butyric acid substituted by a cyclic hydrocarbyl radical, and their acid addition salts and complexes are distinguished by a strong inhibition of the insulin and glucagon secretion of the pancreas and are therefore therapeutically acceptable, preferably in the form of phanmaceutical preparations, in similar indications to those of somatostatin, especially as anti-diabetics. The compounds are manufactured by conventional processes of peptide synthesis, especially by liberation from corresponding protected intermediates after intramolecular cyclisation of a corresponding linear octapeptide.</p>