Peptides affecting gonadal function,申请号US19820353237-传众专利搜索

Peptides affecting gonadal function

申请公布号：US4382922(A)

申请号：US19820353237

申请日期：1982.03.01

申请公布日期：1983.05.10

申请人：

THE SALK INSTITUTE FOR BIOLOGICAL STUDIES

发明人：RIVIER, JEAN E. F.;VALE, JR., WYLIE W.

分类号：A61K38/00;C07K7/16;C07K7/23;(IPC1-7):A61K37/00;C07C103/52

主分类号：A61K38/00

摘要：LRF analogs having a modified D-Phe residue in the 6-position act as superagonists exhibiting potencies many times more than that of LRF. The peptides or their nontoxic salts can be administered by intravenous, subcutaneous, sublingual, oral, intravaginal, intranasal or rectal routes. The peptides can be used to regulate fertility in male and female mammals, including human beings. The peptides are represented by the following formula: p-Glu-His-Trp-Ser-Ty-R1-Leu-Arg-Pro-NH-CH2-CH3 wherein R1 is selected from the group consisting of methyl-D-Phe, nitro-D-Phe, and methyoxy-D-Phe.