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PROCESS FOR PREPARING MORANOLINE DERIVATIVES

申请公布号:KR820001081(B1)

申请号:KR19810002760

申请日期:1981.07.29

申请公布日期:1982.06.21

申请人:
JAPAN NEW MEDICINES CO LTD

发明人:MASMURA S;YOSHIKUNI Y;ENOMOTO H;KURA K;YAOYAKI Y;YAKI M

分类号:A61K31/445;C07D211/46;(IPC1-7):C07D211/46;A61K31/44

主分类号:A61K31/445

摘要:Moranolines (I; R = H, Me, Et, Ph) useful as blood sugar lowering agent, were prepd. Thus, 3.0 g N-β-hydroxyethyltetra-o-benzylmoranoline was heated in 10 ml thionylchloride and 20 ml toluene was added. The result residue in 10 ml methylcellusolve was refluxed with 500 mg thiourea and 10 ml 10% NaOH was added to give I (R = H).

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