PROCESS FOR PREPARING 4-OXO-BENZOPYRAN DERIVATES,申请号CA19780316937-传众专利搜索

PROCESS FOR PREPARING 4-OXO-BENZOPYRAN DERIVATES

申请公布号：CA1117540(A)

申请号：CA19780316937

申请日期：1978.11.27

申请公布日期：1982.02.02

申请人：

FISONS LIMITED

发明人：MURPHY, FINNBARR;WILLIAMS, PETER

分类号：C07D257/04;C07D257/06;C07D311/24;C07D311/92;C07D405/04;C07D493/04;(IPC1-7):C07D311/66

主分类号：C07D257/04

摘要：<p>There is described a process for the production of a compound of formula I, I in which R5, R6, R7 and R8 can be a variety of substituents, and E is a -COOH group or an N-(tetrazol-5-yl)carboxamide group, or a pharmaceutically acceptable derivative thereof, which comprises selective hydrolysis or oxidation of a compound of formula II or IV, II IV or an ester of either thereof, in each pair of Y and Z, Z is hydrogen and Y is hydrogen or hydroxy, or, when the reaction involves hydrolysis, in each pair c? Y and Z both Y and Z are halogen. The compounds produced by the novel process claimed are pharmaceutically useful, e.g. as anti-allergics.</p>