SUBSTITUTED 1-PHENYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINES,PROCESS FOR THE PREPARATION THEREOF,AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM,申请号ZA19790002044-传众专利搜索

SUBSTITUTED 1-PHENYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINES,PROCESS FOR THE PREPARATION THEREOF,AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

申请公布号：ZA7902044(B)

申请号：ZA19790002044

申请日期：1979.04.27

申请公布日期：1980.05.28

申请人：

SCHERICO LTD

分类号：C07D223/16

主分类号：C07D223/16

摘要：Disclosed are novel 7-substituted 8-hydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines of the general formula I <CHEM> wherein X is chloro, bromo or trifluoromethyl, and the pharmaceutically acceptable acid addition salts thereof. The novel compounds may be prepared by methods known per se. Preferably the compounds are prepared by dealkylation of a corresponding 8-alkoxy-1-phenyl-2,3,4,5-tetrahydro-1H-benzazepine at position 8. The novel compounds are useful as intermediates in the preparation of corresponding esters and carbamates and show neuroleptic, antidepressive and antiagressive activity.