7-ACYLAMINO- OG 7-AMINO-3-TRIFLUORMETHYLSULFONYLOXY-1-CARBA-3-CEPHEM-4-CARBOXYLSYRER OG ESTERE OG SALTE DERAF,申请号DK19860003357-传众专利搜索

7-ACYLAMINO- OG 7-AMINO-3-TRIFLUORMETHYLSULFONYLOXY-1-CARBA-3-CEPHEM-4-CARBOXYLSYRER OG ESTERE OG SALTE DERAF

申请公布号：DK335786(D0)

申请号：DK19860003357

申请日期：1986.07.15

申请公布日期：1986.07.15

申请人：

PRESIDENT AND FELLOWS OF HARVARD COLLEGE

发明人：EVANS DAVID ALBERT;SJOGREN ERIC BRIAN

分类号：C07D413/04;A61K31/435;A61P31/04;C07D401/04;C07D413/14;C07D463/00;C07D471/04;(IPC1-7):C07D/

主分类号：C07D413/04

摘要：<p>7 beta -Acylamino-3-trifluoromethylsulfonyloxy-1-carba-3-cephem-4-carboxylic acid antibiotic compounds, esters and salts thereof, and the corresponding 7-amino and protected 7-amino 1-carbacephalosporins are provided. The 3-trifluoromethylsulfonyloxy-substituted 1-carbacephalosporins also are useful in a process for preparing 3-halo-1-carbacephalosporins which comprises reacting a 3-triflate ester with a lithium halide in an aprotic polar solvent.</p>