FORFARANDE FOR FRASTELLNING AV DIOXANDERIVAT MED TERAPEUTISK, SERSKILT ANALGETISK VERKAN,申请号SE19730016586-传众专利搜索

FORFARANDE FOR FRASTELLNING AV DIOXANDERIVAT MED TERAPEUTISK, SERSKILT ANALGETISK VERKAN

申请公布号：SE403377(B)

申请号：SE19730016586

申请日期：1973.12.07

申请公布日期：1978.08.14

申请人：

ELI * LILLY AND COMPANY

发明人：R N * BOOHER

分类号：C07C69/618;A61K31/335;A61K31/357;A61K31/44;A61K31/443;A61K31/445;A61P25/04;B01J23/00;C07B61/00;C07C67/00;C07C213/00;C07C215/10;C07C215/28;C07C215/56;C07C217/64;C07C227/00;C07C227/08;C07D213/38;C07D213/55;C07D319/06;C07D405/06;(IPC1-7):07D319/06;07D405/06

主分类号：C07C69/618

摘要：1455998 2 - [α- (Substituted) - aminobenzyl] - 1,3 - propanediols ELI LILLY & CO 10 Dec 1973 [8 Dec 1972] 29003/76 Divided out of 1455997 Heading C2C Novel compounds of Formula I wherein R and R<SP>1</SP> are C 1 -C 4 alkyl or C 2 -C 4 alkenyl or when taken together with the nitrogen to which they are attached, are aziridino, pyrrolidino or piperidino; and Ar is phenyl, halophenyl, methoxyphenyl, methylphenyl, trifluoromethylphenyl, hydroxyphenyl, acetoxyphenyl, benzyloxyphenyl, or 3-pyridyl as well as compounds wherein R<SP>1</SP> is also H or benzyl and R is also benzyl are prepared by reacting a di-C 1-6 -alkylbenzalmalonate with an amine of formula HNRR<SP>1</SP> to form an intermediate di- C 1-6 -alkyl-(α-RR<SP>1</SP>N-)-benzylmalonate which is reduced to give a comound of Formula I. The dialkyl benzal malonate is obtained by reacting a substituted benzaldehyde ArCHO with a dialkyl malonate.