METHOD FOR PREPARATION OF 3-KETOGLUTARIC ACID,申请号CS19740004324-传众专利搜索

METHOD FOR PREPARATION OF 3-KETOGLUTARIC ACID

申请公布号：CS178923(B2)

申请号：CS19740004324

申请日期：1974.06.19

申请公布日期：1977.10.31

申请人：

MONTEDISON S.P.A.,IT

发明人：ALNERI,ENZO,IT;BOTTACCIO,GIORGIO,IT;CARLETTI,VITTORIO,IT;LANA,GIULIO,IT

分类号：C07C59/347;C07C51/00;C07C51/15;C07C59/265;C07C67/00;(IPC1-7):07C59/33;07C59/16

主分类号：C07C59/347

摘要：<p>1414612 3-Keto-glutaric acid MONT EDISON SpA 12 June 1974 [20 June 1973] 26085/74 Heading C2C In the preparation of 3-keto-glutaric acid by carboxylation of acetone in the presence of an alkali metal phenate and an alkyl ether of a polyethylene glycol R-O-(-CH 2 -CH 2 -O-)- n R, where R is alkyl 1-4 C, and n an integer 1-10, the reaction mixture is degassed from carbon dioxide dissolved and/or complexed with the alkali metal phenate by the addition of at least a stoichiometric quantity of phenol, under vacuum. The aqueous solution is acidified and extracted with diethyl ether to obtain the acid. Tetrapolyethylene glycol in which n is 4 and the R is methyl, is preferred. Citric acid may be prepared by cyanuration of the sodium salt, hydrolysis of the cyanhydrin and neutralization followed by extraction and crystallization.</p>