VIRAL CONJUNCTIVITIS TREATMENT USING RANPIRNASE AND/OR AMPHINASE,申请号WO2016US53629-传众专利搜索

VIRAL CONJUNCTIVITIS TREATMENT USING RANPIRNASE AND/OR AMPHINASE

申请公布号：WO2017053923(A1)

申请号：WO2016US53629

申请日期：2016.09.25

申请公布日期：2017.03.30

申请人：

OKOGEN, LLC

发明人：STREM, Brian

分类号：C12N15/113;A61K38/46

主分类号：C12N15/113

摘要：The present specification discloses Ranpirnase and Amphinase, compositions comprising Ranpirnase and/or Amphinase, and methods and uses to treat a viral conjunctivitis, an epidemic keratoconjunctivitis, and/or a pharyngoconjunctival fever, reduce or suppress a level of virus or viral titer, reduce or suppress viral replication, reduce or suppress protein synthesis, reduce or suppress a level of a tRNA, reduce or suppress a level of an inflammation inducing molecule and/or an inflammation inducing prostaglandin, stimulate or enhance a peroxisome proliferator-activated receptor (PPAR) pathway signal, promote the resolving phenotypic change of M1 to M2, modulate Th1 and Th2 cytokines, and/or reduce or suppress a NFkB pathway signal using Ranpirnase, Amphinase or compositions comprising Ranpirnase and/or Amphinase.