Second generation fatty acid compositions, formulations, and methods of use and synthesis thereof,申请号US201414215395-传众专利搜索

Second generation fatty acid compositions, formulations, and methods of use and synthesis thereof

申请公布号：US9295658(B2)

申请号：US201414215395

申请日期：2014.03.17

申请公布日期：2016.03.29

发明人：Quay Steven C.

分类号：A61K31/16;A61K31/353;A23L1/30;A61K9/14;A61K9/48;A61K31/355;A61K31/164

主分类号：A61K31/16

代理机构：

Pryor Cashman LLP

代理人：Langsam Andrew S.;Pryor Cashman LLP

摘要：An orally administered fatty acid composition for the treatment of cardiovascular diseases, and a method of treating same, are provided. The compound includes 5Z,8Z,11Z,14Z,17Z-eicosapentaenoic ethanolamide (EPA ethanolamide), 4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoic ethanolamide (DHA ethanolamide), and at least one tocotrienol. The EPA ethanolamide and the DHA ethanolamide are preferably each substantially in a range of 100-900 mg per dosage form. The at least one tocotrienol is substantially in a range of 10-500 mg per dosage form. The at least one tocotrienol includes at least one of α-tocotrienol, β-tocotrienol, γ-tocotrienol, or δ-tocotrienol and is preferably substantially tocopherol-free. The composition may take the form of a medical food or a pharmaceutical preparation. A preferred formulation of the composition includes approximately 525 mg EPA ethanolamide, approximately 315 mg DHA ethanolamide, and approximately 50 mg δ-tocotrienol. The EPA and DHA ethanolamides may be synthesized from fatty acid triglycerides.

主权项：1. An orally administered fatty acid composition, for treating high triglycerides and cholesterol in the form of LDL-C comprising: an unsaturated Omega-3 Fatty acid amide composition comprising: 5Z,8Z,11Z,14Z,17Z-eicosapentaenoic ethanolamide (EPA ethanolamide);4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoic ethanolamide (DHA ethanolamide);at least one of α, β, γ or δ tocotrienol, wherein said tocotrienol is tocopherol-free; and wherein said composition has a total aerobic plate count per g/mL of less than 20,000 cfu.