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SILK FIBROIN SYSTEMS FOR ANTIBIOTIC DELIVERY

申请公布号:EP2403551(A2)

申请号:EP20100783739

申请日期:2010.03.04

申请公布日期:2012.01.11

申请人:
TRUSTEES OF TUFTS COLLEGE

发明人:KAPLAN, DAVID, L.;PANILAITIS, BRUCE;PRITCHARD, ELEANOR, M.;OMENETTO, FIORENZO;AXELRAD, JORDAN

分类号:A61L27/40;A61K9/00;A61K9/16;A61K9/70;A61K31/43;A61K31/546;A61K31/7036;A61K45/06;A61K47/46;A61L15/40;A61L15/44;A61L27/36;A61L27/54;A61P31/00;C07K14/435

主分类号:A61L27/40

摘要:<p>The present invention provides for silk fibroin-based compositions comprising one or more antibiotic agents for prevention or treatment of microbial contamination, methods of making antibiotic-containing silk scaffold, methods of stabilizing antibiotics in silk scaffolds, and methods for preventing or treating microbial contamination using the antibiotic-containing compositions. Various methods may be used to embed the antibiotic(s) into the silk fibroin-based compositions. The antibiotic-containing compositions of the invention are particular useful for stabilizing antibiotics, preventing bacterial infections, and for medical implants, tissue engineering, drug delivery systems, or other pharmaceutical or medical applications.</p>

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