OXAZOLIDINE DERIVATIVES AS NMDA ANTAGONISTS,申请号WO2009CN70178-传众专利搜索

OXAZOLIDINE DERIVATIVES AS NMDA ANTAGONISTS

申请公布号：WO2009092324(A1)

申请号：WO2009CN70178

申请日期：2009.01.16

申请公布日期：2009.07.30

申请人：

HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY;IP, NANCY YUK-YU;ZHU, HUA-JIE;IP, FANNY CHUI-FUN

发明人：IP, NANCY YUK-YU;ZHU, HUA-JIE;IP, FANNY CHUI-FUN

分类号：A61K31/421;C07D263/04;A61K31/422;A61P25/00;A61P25/16;A61P25/28;C07D413/06

主分类号：A61K31/421

摘要：<p>The present invention provides therapeutically active oxazolidine derivatives and compositions as NMDA antagonists, which are useful in preventing and treating central nervous system disorders by inhibiting over-activation of NMDA receptors. In one aspect, the present invention provides methods of treating and/or preventing neurodegenerative diseases and neuropathological disorders, methods of providing neuroprotection under stress conditions such as a stroke, and methods of enhancing the brain's cognitive functions in mammals and humans. For example, the compounds can prevent glutamate-induced neuro- toxicity by inhibiting the activities of the NMDA receptor in the presence of toxic doses of NMDA. In addition, the compounds can potentiate the calcium current in the presence of low dose of NMDA.</p>