TNFalpha antagonists and methotrexate in the treatment of TNF-mediated disease

申请公布号：US2009175859(A1)

申请号：US20080287340

申请日期：2008.10.07

申请公布日期：2009.07.09

申请人：

THE KENNEDY INSTITUTE OF RHEUMATOLOGY

发明人：FELDMANN MARC;MAINI RAVINDER NATH

分类号：A61K39/395;A61K31/505;A61K38/00;A61K38/17;A61P19/02;A61P37/00;C07K16/24

主分类号：A61K39/395

摘要：Methods for treating and/or preventing a TNF-mediated disease in an individual are disclosed. Also disclosed is a composition comprising methotrexate and an anti-tumor necrosis factor antibody. TNF-mediated diseases include rheumatoid arthritis, Crohn's disease, and acute and chronic immune diseases associated with transplantation.

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