6-METHYLNICOTINEAMIDE DERIVATIVES USEFUL AS ANTIVIRAL AGENTS,申请号KR20000020137-传众专利搜索

6-METHYLNICOTINEAMIDE DERIVATIVES USEFUL AS ANTIVIRAL AGENTS

申请公布号：KR20010096176(A)

申请号：KR20000020137

申请日期：2000.04.17

申请公布日期：2001.11.07

申请人：

DONG WHA PHARM. IND. CO., LTD.

发明人：KIM, JONG U;KIM, NAM DU;LEE, GEUN HYEONG;LEE, HAK DONG;LEE, JIN SU;LEE, SANG UK;PARK, HUI JEONG;PARK, SANG JIN;YOON, SEONG JUN

分类号：C07D417/06;(IPC1-7):C07D417/06

主分类号：C07D417/06

摘要：PURPOSE: 6-methylnicotineamide derivatives useful as antiviral agents are provided, thereby inhibiting the growth of hepatitis B virus(HBV), hepatitis C virus(HCV) and human immunodeficiency virus(HIV). CONSTITUTION: The 6-methylnicotineamide derivatives are represented by formula(1), in which R1 is hydroxy, C1 to C5 linear or branched alkyl, C3 to C6 cyclo alkyl, C2 to C6 dialkylamino, or saturated or unsaturated hetero ring having 5 or 6 atoms, in which the hetero ring comprises 1 to 2 hetero atoms selected from N, O or S, and unsubstituted or substituted with C1 to C3 alkyl; and m is an integer of 0 or 1; R2 is hydrogen or C1 to C4 alkyl; or both R1 and R2 form hetero ring having 5 to 6 atoms, in which the hetero ring comprises 1 to 2 hetero atoms selected from N, O or S; and n is an integer of 0 to 4.