Cyklopentan- og penten-beta-aminosyrer,申请号NO19930001718-传众专利搜索

Cyklopentan- og penten-beta-aminosyrer

申请公布号：NO931718(A)

申请号：NO19930001718

申请日期：1993.05.11

申请公布日期：1993.11.30

申请人：

BAYER AKTIENGESELLSCHAFT

发明人：MITTENDORF, JOACHIM;KUNISCH, FRANZ;MATZKE, MICHAEL;MILITZER, HANS-CHRISTIAN;ENDERMANN, RAINER;METZGER, KARL GEORG;BREMM, KLAUS-DIETER;PLEMPEL, MANFRED

分类号：A61K31/16;A61K31/19;A61K31/195;A61K31/196;A61K31/215;A61K31/275;A61P31/00;A61P31/04;A61P31/10;A61P43/00;C07C61/15;C07C61/20;C07C61/35;C07C61/39;C07C61/40;C07C69/74;C07C69/753;C07C69/757;C07C229/48;C07C237/04;C07C239/18;C07C251/42;C07C271/20;C07C271/22;C07C271/24;C07C271/34;C07C271/36;C07D265/12;C07D307/93;(IPC1-7):C07C229/48

主分类号：A61K31/16

摘要：<p>Cyclopentane- and -pentene- beta -amino acids of the general formula (I) <IMAGE> in which A, B, D, E, G, L, M and T are identical or different and, with the proviso that at least one of the abovementioned substituents is H, represents hydrogen, halogen, benzyl, hydroxyl or optionally substituted alkyl with up to 8 carbon atoms, or in each case B and D, E and G or L and M together represent a radical of the formula <IMAGE> or =N-OH, or E and G and/or B and D together represent the radical of the formula =O or =S, or B, D, E and G or E, G, L and M each together form a radical of the formula <IMAGE> in which D' and G' have the abovementioned meaning of D and G, but do not both denote hydrogen and G and L have the abovementioned meaning V is an oxygen or sulphur atom or the -NH group, R<1> is hydrogen, optionally substituted alkyl or optionally substituted phenyl or, if V is the -NH group, is the group of the formula -SO2R<8>, R<2> is hydrogen, an amino protective group customary in peptide chemistry, optionally substituted alkyl with up to 8 carbon atoms, acyl with up to 8 carbon atoms, optionally substituted benzoyl, a group of the formula -SO2R<8> or an amino acid residue of the formula <IMAGE> R<3> is hydrogen or optionally phenyl-substituted alkyl with up to 8 carbon atoms, or R<2> and R<3> together represent the radical of the formula =CHR<14>, process for their preparation and their use as pharmaceuticals, especially antimycotic pharmaceuticals, are described.</p>