PEPTIDE-LIPID CONSTRUCTS AND THEIR USE IN DIAGNOSTIC AND THERAPEUTIC APPLICATIONS,申请号CA20082699366-传众专利搜索

PEPTIDE-LIPID CONSTRUCTS AND THEIR USE IN DIAGNOSTIC AND THERAPEUTIC APPLICATIONS

申请公布号：CA2699366(A1)

申请号：CA20082699366

申请日期：2008.09.11

申请公布日期：2009.03.19

申请人：

BOVIN, NICOLAI;WEINBERG, CRISTINA-SIMONA;HENRY, SEPHEN MICHEAL

发明人：BOVIN, NICOLAI;WEINBERG, CRISTINA-SIMONA;HENRY, SEPHEN MICHEAL

分类号：G01N33/539;A61K39/385;C07F9/10;C07K1/02;C07K1/04;C07K17/08;G01N33/53;G01N33/531;G01N33/536;G01N33/564;G01N33/68;G01N33/92

主分类号：G01N33/539

摘要：Peptide-lipid constructs of the structure L-S-F are disclosed, where F is a peptide, S is a spacer covalently linking F to L via an oligomer of ethylene glycol, and L is a diacyl- or dialkyl-glycerolipid (including glycerophospholipids). The spacer ideally has 6 to 14 ethylene glycol repeats, corresponding to PEG with a molecular weight of approximately 250 to 600. Also disclosed is a method of detecting reactive antibodies in serum by contacting serum with cells modified to incorporate a peptide-lipid construct, where the peptide is an epitope of the antibody, and determining the degree of agglutination of the cells.