ORGANOTIN COMPOUNDS DERIVED FROM UROCANIC ACID WITH ANTITUMOR ACTIVITY.,申请号MX20120012415-传众专利搜索

ORGANOTIN COMPOUNDS DERIVED FROM UROCANIC ACID WITH ANTITUMOR ACTIVITY.

申请公布号：MX2012012415(A)

申请号：MX20120012415

申请日期：2012.10.24

申请公布日期：2014.04.28

申请人：

UNIVERSIDAD AUTONOMA METROPOLITANA.*

发明人：CARLOS CAMACHO CAMACHO;IRMA ROJAS OVIEDO;ARIADNA GARZA ORTIZ

分类号：A61K31/21;A61K31/215;A61K31/40

主分类号：A61K31/21

摘要：The present invention refers to the preparation of novel derivatives of urocanic acid: tri-n-butyltin (IV) carboxylate and triphenyltin (IV) carboxylate, compounds which formulas are [(C6H5N202) Sn (CH2CH2CH2CH3)3](I) and [(C6H5N2O2)Sn(C6H5)3] (II) respectively. Where the compounds coordinated with tin are formed by the reaction between an organotin and 4-imidazolacrylic acid (urocanic acid) by means of a process that includes the preparation of a reactant mixture, the synthesis by reflux and the mixture and purification of the derivatives by recrystallization. The novel derivatives present antitumor activity in vitro against the growth of cancer cells of human origin: U251 (glia of central nervous system), PC-3(prostate), K562 (leukemia), HTC-15 (colon), MCF-7 (breast) and SKLU (lung).